The fundamental flaw I've seen in all managment initiatives is the failure to account for the toxic effect of human motivators. Under stress most people slip down the evolutionary ladder and operate on their most base needs. Organizations routinely ignore these forces. Even worse, some of the most toxic individuals are rewarded for delivering bottom-line results, even when the human cost of those results fundamentally undermines the long term effectiveness of the organization. The answer is to include the human element in management planning and deliver consequences for toxic behavior.
USA schools are an imperfect but notable example. Despite the widespread publicity of a few cyber-bulling incidents, bullying in many schools has greatly diminshed. Those improvements only happened when schools stopped ignoring bullies and made significant changes to reduce toxic behavior. There is a lot more that can be done.